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Chuchuhuasi (Maytenus krukovii, Maytenus laevis,Maytenus macrocarpa)
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Chuchuhuasi/Drug Interactions:- AntibioticsAntibiotics: In lab study, an ethanolic extract of Maytenus macrocarpa demonstrated the broadest spectrum of action, inhibiting all of the tested strains with MICs ranging from 125-250mcg/mL (4). In other study, however, extracts of Maytenus macrocarpa (5) and Maytenus krukovii (6) bark lacked antibacterial activity.
- AntifungalsAntifungals: Based on in vitro evidence, the hydroalcoholic extract of Maytenus krukovii bark demonstrated weak antifungal activity against dermatophyte and phytopathogenic fungi (unspecified), although it inhibited the growth of phytopathogen Pythium ultimum (6).
- Anti inflammatory agentsAnti inflammatory agents: The anti-inflammatory effects of chuchuhuasi (most likely Maytenus laevis) may be due to the presence of phenoldienones (tingenone, 22-hydroxytingenone), a catechin (4'-methyl-(-)-epigallocatechin), and proanthocyanidins (ouratea-proanthocyanidins A and B) (7).
- AntineoplasticsAntineoplastics: Based on in vitro evidence, constituents of Maytenus macrocarpa demonstrated marginal antitumor activity against four cell lines (unspecified) (8). In lab study, canophyllol from Maytenus laevis demonstrated antitumor effects (9).
- AntiprotozoalsAntiprotozoals: Based on in vitro evidence, sesquiterpenes isolated from Maytenus macrocarpa may have antiparasitic activity against a multidrug-resistant Leishmania tropica line (10).
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Chuchuhuasi/Herb/Supplement Interactions:- AntibacterialsAntibacterials: In lab study, an ethanolic extract of Maytenus macrocarpa demonstrated the broadest spectrum of action, inhibiting all of the tested strains with MICs ranging from 125 - 250mcg/mL (4). In other study, however, extracts of Maytenus macrocarpa (5) and Maytenus krukovii (6) bark lacked antibacterial activity.
- AntifungalsAntifungals: Based on in vitro evidence, the hydroalcoholic extract of Maytenus krukovii bark demonstrated weak antifungal activity against dermatophyte and phytopathogenic fungi (unspecified), although it inhibited the growth of phytopathogen Pythium ultimum (6).
- Anti-inflammatory herbsAnti-inflammatory herbs: The anti-inflammatory effects of chuchuhuasi (most likely Maytenus laevis) may be due to the presence of phenoldienones (tingenone, 22-hydroxytingenone), a catechin (4'-methyl-(-)-epigallocatechin), and proanthocyanidins (ouratea-proanthocyanidins A and B) (7).
- AntineoplasticsAntineoplastics: Based on in vitro evidence, constituents of Maytenus macrocarpa demonstrated marginal antitumor activity against four cell lines (unspecified) (8). In lab study, canophyllol from Maytenus laevis demonstrated antitumor effects (9).
- AntioxidantsAntioxidants: Based on in vitro evidence, the hydroalcoholic extract of Maytenus krukovii bark showed radical-scavenging activity (6). Based on secondary sources, Maytenus guyanensis Klotzch. bark demonstrated antioxidant activity in vitro, based on tests involving reactions with 2,2,-diphenyl-1-picrylhydrazyl (DPPH).
- AntiparasiticsAntiparasitics: Based on in vitro evidence, sesquiterpenes isolated from Maytenus macrocarpa may have antiparasitic activity against a multidrug-resistant Leishmania tropica line (10). A constituent isolated from Maytenus boaria seeds demonstrated antiparasitic effects against Spodoptera frugiperda with an LD50 value of 1.9ppm (11).
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Chuchuhuasi/Food Interactions:- Insufficient available evidence.
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Chuchuhuasi/Lab Interactions:- Insufficient available evidence.
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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