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Black mulberry (Morus nigra)
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Black mulberry/Drug Interactions:- Antidiabetic agentsAntidiabetic agents: Black mulberry may alter glucose levels.
- Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on in vitro study, black mulberry may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).
- MidazolamMidazolam: Commercial fruit juices, such as black mulberry juice, may have inhibitory effects on midazolam 1'-hydroxylase activity, a marker of CYP3A (2).
- Sedative drugsSedative drugs: Mulberry has been traditionally used as a sedative.
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Black mulberry/Herb/Supplement Interactions:- Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on in vitro study, black mulberry may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).
- FigFig: A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to fig (3).
- HypoglycemicsHypoglycemics: Black mulberry may alter glucose levels.
- MulberryMulberry: A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to red, white and purple mulberry (3).
- SedativesSedatives: Mulberry has been traditionally used as a sedative.
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Black mulberry/Food Interactions:- FigFig A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to fig (3).
- Fruit/Fruit juices (white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape)Fruit/Fruit juices (white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape): Based on in vitro study, black mulberry, white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape juice may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).
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Black mulberry/Lab Interactions:- Blood glucose monitoringBlood glucose monitoring: Black mulberry may alter glucose levels.
- Liver testsLiver tests: Tests for hepatic enzyme activity and liver function may have erroneous results due to the concentration-dependent inhibition of CYP 3A4 enzymes by black mulberry (2).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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